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The direct causal link may be this: At the later Cancun WTO protests that grew out of Seattle, a South Korean farmer climbed stop the barricades and commited suicide, running a knife into his chest. There had been many farmer suicides in S Korea over total economic desperation created by trade deals, but this one was in the face of the WTO.
The next day, 20 African nations empowered by this act and the protests walked out of the talks, and the Doha Round never recovered.

Without the protests, that farmer might never have thought he had the appropriate venue for his sacrifice. Without him, the 20 African nations might have thought they could not get away with walking out. Had they stayed, the Doha Round would probably have become the Doha Trade Treaty(or some other name).

Yes, Seattle, A16 (DC), Prague, Philadelphia (RNC 2000),Quebec, Cancun, and Miami were vicious and nasty, but battles always are. Speaking of Miami, everyone I knew who went there considered it a defeat at the time, rather like the US in Vietnam. Now however these same folks consider it a victory because the FTAA was defeated, whatever the cost.