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“do puberty blockers and synthetic hormones have anything to do with attempts at genuine self-creation, disrupting normalcy or subverting authoritarian/mass civilization?“

yes, i consider that by itself it can be part of someone’s “genuine self-creation”, whatever that means (what is the virtue of “authenticity”, dear Socrates?).

by itself, it can only help toward “disrupting normalcy or subverting authoritarian/mass civilization” to a certain degree, until trans itself is normalized and the institutions adapt to a greater degree. trans and queer folx have made great inroads at eroding gender boundaries, definitions and norms, cultural ideas, policies, etc. but liberal discourse (academia playing an important part) is quick to co-opt/recuperate and direct all energies/trends toward liberal democratic centrist voter status quo things.
so by itself, it will never be enough and will only see diminishing returns, even regressive reactionary backlash from the institutions.